I think the Lions would do well to trade it away. Then go for offensive and defensive line. Start building the defense. If I know the kind of coach Jim Schwartz is, and I do, you will see a big emphasis on the defense in this draft. Jeff Fisher 101, strong defense, solid running game, ball control, and smart clock management. If you have the ball the other team can't score on you!
As for my team, the Titans, if we can keep most of our players, (please hold on to Haynesworth), and get a playmaking wide reciever either through the draft or free agency, we should be just fine. That Championship window is wide open for Tennessee right now. Maybe get a little depth on both sides of the line would be good too.
I'm of the opinion it all starts with line play on both sides of the ball. You don't need a team of stars. The team that gets it done in the trenches is usually the team that gets the win. As in:
Steelers
Titans
Ravens
That's the model to follow.