I've had to deal with the heartbreak of psoriasis most of my adult life, and that's a story in itself (but not a very interesting one). So I'll just say that in the old days, the treatment options were poor, but nowadays there are more medications than varieties of Cheez-Its, thanks to the profit-mongers at big pharma.
About 2 years ago, my insurance provider decided that the effective medication I had been using for a dozen years was no longer "preferred", and I had to go onto something which seemed like it would be very similar (based on the insufferable ads for it). This was a few months before moving into the new house.
So after we move in, I'm very sore from hauling all the furniture and stuff. My wrists hurt, my ankles hurt, my feet hurt. The pain and stiffness persists, and it's particularly bad first thing in the morning. But we're still settling into the house, which involves moving heavy things. Then I notice that, weeks after I stop moving stuff, I'm still getting the same joint pain.
Turns out, I've developed psoriatic arthritis (which I had a high likelihood of getting), and the medication I had been on for all those years was treating it. But the new (supposedly similar) drug was not. So I saw a rheumatologist, and he confirmed that drugs which are advertised as working similarly, may or may not be effective for different people.
I was prescribed a different new medication, and after 3 more months of pain (following the 3 months it took to diagnose the issue), it started working just like the original one I had been on for years. So I'm good again.
BTW, all these drugs are obscenely expensive. But strangely, there's a thing called "co-pay assistance", wherein the drug company actually pays my entire copay/deductible, while the insurance company still credits the amount towards my out-of-pocket, because they (insurance) aren't paying. Eventually, I meet my deductible, and then insurance picks up 90-100%, which means the drug company gets their profit. What a great country.