I don't know what would be considered "wife friendly" per se. But in addition to the games mentioned here, I recommend Infamous (an open world super hero game that plays like a shooter), Batman: Arkham Asylum, the original Uncharted and Assassin's Creed seeing as how their sequels have already been mentioned. There's also some good budget titles available for $20. If you want something a little different you may want to look into Mirror's Edge. And if you like old games, they have a Sega Genesis game collection with a lot of classic titles for $20. Also there's PS1 games available for download on PSN.
Also you may want to consult this guide and see what you're interested in.
Playstation 3 - /v/'s Recommended Games Wiki